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MT001693

UniProt Annotations

Entry Information

Gene Name	CD24 molecule
Protein Entry
UniProt ID
Species	Human

Comments

Comment type	Description
Disease	Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269\|PubMed:14657362}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Function	Modulates B-cell activation responses. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells. {ECO:0000269\|PubMed:11313396}.
Induction	Expression is lost when primary B-cells are induced to differentiate in antibody-forming cells.
Interaction	P07948:LYN; NbExp=6; IntAct=EBI-6267018, EBI-79452;
Ptm	Extensively O-glycosylated.
Sequence Caution	Sequence=AAD14170.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the CD24 family. {ECO:0000305}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor.
Subunit	Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma. {ECO:0000269\|PubMed:11313396, ECO:0000269\|PubMed:8753773}.
Tissue Specificity	B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. {ECO:0000269\|PubMed:14657362, ECO:0000269\|PubMed:8753773}.