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MT000070

Record overview

MITO IDMT000070
Gene ID578
SpeciesHomo sapiens (Human)
Gene NameBCL2-antagonist/killer 1
Gene SymbolBAK1
SynonymsBAK; CDN1; BCL2L7; BAK-LIKE;
Alternate namesbcl-2 homologous antagonist/killer; bcl2-L-7; BCL2-like 7 protein; bcl-2-like protein 7; apoptosis regulator BAK; pro-apoptotic protein BAK;
Chromosome6
Map Location6p21.3
SummaryThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BAK1

Proteins

bcl-2 homologous antagonist/killer
Refseq ID:NP_001179
Protein GI:4502363
UniProt ID:Q16611
mRNA ID:NM_001188
Length:211
RefSeq Status:
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHL
QPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLL
GQFVVRRFFKS