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MT000070

UniProt Annotations

Entry Information

Gene Name	BCL2-antagonist/killer 1
Protein Entry	BAK_HUMAN
UniProt ID	Q16611
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q16611-1; Sequence=Displayed; Name=2; IsoId=Q16611-2; Sequence=VSP_056551, VSP_056552; Note=No experimental confirmation available.;
Domain	Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function	In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. {ECO:0000269\|PubMed:17157251, ECO:0000269\|PubMed:8521816}.
Interaction	Self; NbExp=5; IntAct=EBI-519866, EBI-519866; Q07812:BAX; NbExp=5; IntAct=EBI-519866, EBI-516580; Q07817:BCL2L1; NbExp=3; IntAct=EBI-519866, EBI-78035; Q07817-1:BCL2L1; NbExp=10; IntAct=EBI-519866, EBI-287195; P55957:BID; NbExp=2; IntAct=EBI-519866, EBI-519672; Q07820:MCL1; NbExp=10; IntAct=EBI-519866, EBI-1003422; P97287:Mcl1 (xeno); NbExp=3; IntAct=EBI-519866, EBI-707292; P24356:VACWR040 (xeno); NbExp=6; IntAct=EBI-519866, EBI-8041400;
Similarity	Belongs to the Bcl-2 family. {ECO:0000305}.
Subcellular Location	Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Subunit	Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L). Interacts with myxoma virus protein M11L. Interacts with BOP/C22orf29. {ECO:0000250, ECO:0000269\|PubMed:17157251, ECO:0000269\|PubMed:17386268, ECO:0000269\|PubMed:23055042, ECO:0000269\|PubMed:9020082}.
Tissue Specificity	Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BAK1ID752ch6p21.html";
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bak1/";