MitoProteome Database

MT000070

Gene Information

Entrez Gene ID	578
Gene Name	BCL2-antagonist/killer 1
Gene Symbol	BAK1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	IEA:Ensembl	C	cytosol
GO:0005783	IEA:Ensembl	C	endoplasmic reticulum
GO:0031307	ISS:BHF-UCL	C	integral component of mitochondrial outer membrane
GO:0005741	IBA:RefGenome	C	mitochondrial outer membrane
GO:0005739	IDA:HGNC	C	mitochondrion
GO:0046930	IDA:HGNC	C	pore complex
GO:0042802	IPI:IntAct	F	identical protein binding
GO:0046872	IEA:UniProtKB-KW	F	metal ion binding
GO:0046982	IPI:UniProtKB	F	protein heterodimerization activity
GO:0042803	IBA:RefGenome	F	protein homodimerization activity
GO:0097202	IDA:BHF-UCL	P	activation of cysteine-type endopeptidase activity
GO:0008635	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0007568	IEA:Ensembl	P	aging
GO:0006915	TAS:Reactome	P	apoptotic process
GO:1902262	IEA:Ensembl	P	apoptotic process involved in patterning of blood vessels
GO:0097190	IMP:UniProtKB	P	apoptotic signaling pathway
GO:0001783	IEA:Ensembl	P	B cell apoptotic process
GO:0001782	IEA:Ensembl	P	B cell homeostasis
GO:0002352	IEA:Ensembl	P	B cell negative selection
GO:0001974	IEA:Ensembl	P	blood vessel remodeling
GO:0007420	IEA:Ensembl	P	brain development
GO:0008283	IEA:Ensembl	P	cell proliferation
GO:0071260	IEP:UniProtKB	P	cellular response to mechanical stimulus
GO:0034644	IMP:UniProtKB	P	cellular response to UV
GO:0031018	IEA:Ensembl	P	endocrine pancreas development
GO:0032469	TAS:UniProtKB	P	endoplasmic reticulum calcium ion homeostasis
GO:0010248	IDA:HGNC	P	establishment or maintenance of transmembrane electrochemical gradient
GO:0097192	IBA:RefGenome	P	extrinsic apoptotic signaling pathway in absence of ligand
GO:0044346	IEA:Ensembl	P	fibroblast apoptotic process
GO:0097193	TAS:Reactome	P	intrinsic apoptotic signaling pathway
GO:0008630	IBA:RefGenome	P	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0070059	IEA:Ensembl	P	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0035108	IEA:Ensembl	P	limb morphogenesis
GO:0008053	IEA:Ensembl	P	mitochondrial fusion
GO:0002262	IEA:Ensembl	P	myeloid cell homeostasis
GO:0008285	IEA:Ensembl	P	negative regulation of cell proliferation
GO:0032471	IEA:Ensembl	P	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0010629	IEA:Ensembl	P	negative regulation of gene expression
GO:0033137	IEA:Ensembl	P	negative regulation of peptidyl-serine phosphorylation
GO:0031100	IEA:Ensembl	P	organ regeneration
GO:0043065	IMP:UniProtKB	P	positive regulation of apoptotic process
GO:0010524	IEA:Ensembl	P	positive regulation of calcium ion transport into cytosol
GO:1900103	IMP:UniProtKB	P	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030	TAS:Reactome	P	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0045862	IDA:BHF-UCL	P	positive regulation of proteolysis
GO:0090200	IEA:Ensembl	P	positive regulation of release of cytochrome c from mitochondria
GO:0048597	IEA:Ensembl	P	post-embryonic camera-type eye morphogenesis
GO:0051726	IEA:Ensembl	P	regulation of cell cycle
GO:0046902	IDA:BHF-UCL	P	regulation of mitochondrial membrane permeability
GO:0051881	IDA:HGNC	P	regulation of mitochondrial membrane potential
GO:0043497	IDA:HGNC	P	regulation of protein heterodimerization activity
GO:0043496	IDA:HGNC	P	regulation of protein homodimerization activity
GO:0001836	IDA:BHF-UCL	P	release of cytochrome c from mitochondria
GO:0042493	IEA:Ensembl	P	response to drug
GO:0045471	IEA:Ensembl	P	response to ethanol
GO:0009620	IEA:Ensembl	P	response to fungus
GO:0010332	IEA:Ensembl	P	response to gamma radiation
GO:0042542	IEA:Ensembl	P	response to hydrogen peroxide
GO:0010046	IEA:Ensembl	P	response to mycotoxin
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0010225	IEA:Ensembl	P	response to UV-C
GO:0070242	IEA:Ensembl	P	thymocyte apoptotic process
GO:0060068	IEA:Ensembl	P	vagina development

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05206	MicroRNAs in cancer
ko05206	MicroRNAs in cancer
hsa04141	Protein processing in endoplasmic reticulum
ko04141	Protein processing in endoplasmic reticulum
hsa05203	Viral carcinogenesis
ko05203	Viral carcinogenesis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_707	Activation and oligomerization of BAK protein
REACT_578	Apoptosis
REACT_964	Intrinsic Pathway for Apoptosis