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MT000084

Record overview

MITO IDMT000084
Gene ID637
SpeciesHomo sapiens (Human)
Gene NameBH3 interacting domain death agonist
Gene SymbolBID
SynonymsFP497;
Alternate namesBH3-interacting domain death agonist; p22 BID; BID isoform Si6; BID isoform L(2); BID isoform ES(1b); desmocollin type 4; apoptic death agonist; Human BID coding sequence;
Chromosome22
Map Location22q11.1
SummaryThis gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BID

Proteins

BH3-interacting domain death agonist isoform 1
Refseq ID:NP_932070
Protein GI:37574726
UniProt ID:P55957
mRNA ID:NM_197966
Length:241
RefSeq Status:
MCSGAGVMMARWAARGRAGWRSTVRILSPLGHCEPGVSRSCRAAQAMDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGY
DELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALL
LAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD
 
BH3-interacting domain death agonist isoform 2
Refseq ID:NP_001231496
Protein GI:347300410
UniProt ID:P55957
mRNA ID:NM_001244567
Length:195
RefSeq Status:
MDCEVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARHLAQVGDSMDRS
IPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD
 
BH3-interacting domain death agonist isoform 2
Refseq ID:NP_001187
Protein GI:4557361
UniProt ID:P55957
mRNA ID:NM_001196
Length:195
RefSeq Status:
Protein sequence is identical to GI:347300410 (mRNA isoform)
 
BH3-interacting domain death agonist isoform 3
Refseq ID:NP_001231498
Protein GI:347300416
UniProt ID:P55957
mRNA ID:NM_001244569
Length:99
RefSeq Status:
MDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFINQNLRTYVRSLARNGMD
 
BH3-interacting domain death agonist isoform 3
Refseq ID:NP_001231501
Protein GI:347300423
UniProt ID:P55957
mRNA ID:NM_001244572
Length:99
RefSeq Status:
Protein sequence is identical to GI:347300416 (mRNA isoform)
 
BH3-interacting domain death agonist isoform 3
Refseq ID:NP_932071
Protein GI:37574728
UniProt ID:P55957
mRNA ID:NM_197967
Length:99
RefSeq Status:
Protein sequence is identical to GI:347300416 (mRNA isoform)
 
BH3-interacting domain death agonist isoform 3
Refseq ID:NP_001231499
Protein GI:347300418
UniProt ID:P55957
mRNA ID:NM_001244570
Length:99
RefSeq Status:
Protein sequence is identical to GI:347300416 (mRNA isoform)