MitoProteome Database

MT000084

Gene Information

Entrez Gene ID	637
Gene Name	BH3 interacting domain death agonist
Gene Symbol	BID
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProt	C	extracellular vesicular exosome
GO:0032592	IEA:Ensembl	C	integral component of mitochondrial membrane
GO:0016020	TAS:ProtInc	C	membrane
GO:0005741	TAS:Reactome	C	mitochondrial outer membrane
GO:0005739	TAS:ProtInc	C	mitochondrion
GO:0005123	TAS:ProtInc	F	death receptor binding
GO:0006919	IEA:Ensembl	P	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008637	TAS:ProtInc	P	apoptotic mitochondrial changes
GO:0006915	TAS:Reactome	P	apoptotic process
GO:0007420	IEA:Ensembl	P	brain development
GO:0090150	IDA:BHF-UCL	P	establishment of protein localization to membrane
GO:0008625	TAS:ProtInc	P	extrinsic apoptotic signaling pathway via death domain receptors
GO:0034349	IEA:Ensembl	P	glial cell apoptotic process
GO:0097193	TAS:Reactome	P	intrinsic apoptotic signaling pathway
GO:0051402	TAS:HGNC	P	neuron apoptotic process
GO:0043065	IMP:UniProtKB	P	positive regulation of apoptotic process
GO:2001238	IMP:UniProtKB	P	positive regulation of extrinsic apoptotic signaling pathway
GO:2001244	TAS:Reactome	P	positive regulation of intrinsic apoptotic signaling pathway
GO:1901030	TAS:Reactome	P	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:0032464	IDA:BHF-UCL	P	positive regulation of protein homooligomerization
GO:1900740	TAS:Reactome	P	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0032461	IDA:UniProtKB	P	positive regulation of protein oligomerization
GO:0090200	IMP:UniProtKB	P	positive regulation of release of cytochrome c from mitochondria
GO:0051260	IEA:Ensembl	P	protein homooligomerization
GO:0006626	IEA:Ensembl	P	protein targeting to mitochondrion
GO:0042127	IEA:Ensembl	P	regulation of cell proliferation
GO:2000045	IEA:Ensembl	P	regulation of G1/S transition of mitotic cell cycle
GO:1902108	IEA:Ensembl	P	regulation of mitochondrial membrane permeability involved in apoptotic process
GO:0001836	IDA:HGNC	P	release of cytochrome c from mitochondria
GO:0032355	IEA:Ensembl	P	response to estradiol
GO:0042770	TAS:UniProtKB	P	signal transduction in response to DNA damage

KEGG Pathway Links

KEGG Pathway ID	Description
hsa05010	Alzheimer's disease
ko05010	Alzheimer's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
ko05014	Amyotrophic lateral sclerosis (ALS)
hsa04210	Apoptosis
ko04210	Apoptosis
hsa04650	Natural killer cell mediated cytotoxicity
ko04650	Natural killer cell mediated cytotoxicity
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
ko04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04115	p53 signaling pathway
ko04115	p53 signaling pathway
hsa05200	Pathways in cancer
hsa05152	Tuberculosis
ko05152	Tuberculosis
hsa05416	Viral myocarditis

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_707	Activation and oligomerization of BAK protein
REACT_701	Activation, myristolyation of BID and translocation to mitochondria
REACT_549	Activation of BAD and translocation to mitochondria
REACT_697	Activation of BH3-only proteins
REACT_584	Activation, translocation and oligomerization of BAX
REACT_578	Apoptosis
REACT_330	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_964	Intrinsic Pathway for Apoptosis