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MT000084

UniProt Annotations

Entry Information

Gene Name	BH3 interacting domain death agonist
Protein Entry	BID_HUMAN
UniProt ID	P55957
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=BID(L); IsoId=P55957-1; Sequence=Displayed; Name=2; Synonyms=BID(EL); IsoId=P55957-2; Sequence=VSP_017267; Name=3; Synonyms=BID(S); IsoId=P55957-3; Sequence=VSP_017268, VSP_017269; Name=4; Synonyms=BID(ES); IsoId=P55957-4; Sequence=VSP_017266;
Domain	Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Function	The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250, ECO:0000269\|PubMed:14583606}.
Interaction	Q16611:BAK1; NbExp=2; IntAct=EBI-519672, EBI-519866; Q07812:BAX; NbExp=16; IntAct=EBI-519672, EBI-516580; P10415:BCL2; NbExp=8; IntAct=EBI-519672, EBI-77694; Q07440:Bcl2a1 (xeno); NbExp=3; IntAct=EBI-519672, EBI-707754; Q07817:BCL2L1; NbExp=2; IntAct=EBI-519672, EBI-78035; Q07817-1:BCL2L1; NbExp=6; IntAct=EBI-519672, EBI-287195; Q92843:BCL2L2; NbExp=5; IntAct=EBI-519672, EBI-707714; Q03135:CAV1; NbExp=3; IntAct=EBI-519672, EBI-603614; P17361:VACWR028 (xeno); NbExp=2; IntAct=EBI-519672, EBI-7115640;
Ptm	p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. {ECO:0000269\|PubMed:20392206}.
Ptm	TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products. {ECO:0000250}.
Sequence Caution	Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Subcellular Location	BH3-interacting domain death agonist p13: Mitochondrion membrane {ECO:0000250}. Note=Associated with the mitochondrial membrane. {ECO:0000250}.
Subcellular Location	BH3-interacting domain death agonist p15: Mitochondrion membrane {ECO:0000250}. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Mitochondrion membrane {ECO:0000250}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269\|PubMed:14583606}.
Subcellular Location	Isoform 1: Cytoplasm.
Subcellular Location	Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.
Subcellular Location	Isoform 3: Cytoplasm.
Subunit	Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH. {ECO:0000250, ECO:0000269\|PubMed:20392206}.
Tissue Specificity	Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). {ECO:0000269\|PubMed:14583606}.
Web Resource	Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bid/";