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MT000128

Record overview

MITO IDMT000128
Gene ID1312
SpeciesHomo sapiens (Human)
Gene Namecatechol-O-methyltransferase
Gene SymbolCOMT
SynonymsHEL-S-98n;
Alternate namescatechol O-methyltransferase; epididymis secretory sperm binding protein Li 98n;
Chromosome22
Map Location22q11.21
EC Number2.1.1.6;
SummaryCatechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
OrthologsView orthologs and multiple alignments for COMT

Proteins

catechol O-methyltransferase isoform MB-COMT
Refseq ID:NP_001128633
Protein GI:205830451
UniProt ID:P21964
mRNA ID:NM_001135161
Length:271
RefSeq Status:
MPEAPPLLLAAVLLGLVLLVVLLLLLRHWGWGLCLIGWNEFILQPIHNLLMGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIV
DAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQRMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPD
TLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEYREVVDGLEKAIYKGPGSEAGP
 
catechol O-methyltransferase isoform MB-COMT
Refseq ID:NP_000745
Protein GI:4502969
UniProt ID:P21964
mRNA ID:NM_000754
Length:271
RefSeq Status:
Protein sequence is identical to GI:205830451 (mRNA isoform)
 
catechol O-methyltransferase isoform MB-COMT
Refseq ID:NP_001128634
Protein GI:205830453
UniProt ID:P21964
mRNA ID:NM_001135162
Length:271
RefSeq Status:
Protein sequence is identical to GI:205830451 (mRNA isoform)
 
catechol O-methyltransferase isoform S-COMT
Refseq ID:NP_009294
Protein GI:6466450
UniProt ID:P21964
mRNA ID:NM_007310
Length:221
RefSeq Status:
MGDTKEQRILNHVLQHAEPGNAQSVLEAIDTYCEQKEWAMNVGDKKGKIVDAVIQEHQPSVLLELGAYCGYSAVRMARLLSPGARLITIEINPDCAAITQ
RMVDFAGVKDKVTLVVGASQDIIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVICPGAPDFLAHVRGSSCFECTHYQSFLEY
REVVDGLEKAIYKGPGSEAGP