MitoProteome Database

MT000128

Gene Information

Entrez Gene ID	1312
Gene Name	catechol-O-methyltransferase
Gene Symbol	COMT
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005829	TAS:Reactome	C	cytosol
GO:0070062	IDA:UniProtKB	C	extracellular vesicular exosome
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0016020	IDA:UniProtKB	C	membrane
GO:0005739	IEA:Ensembl	C	mitochondrion
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0016206	IEA:UniProtKB-EC	F	catechol O-methyltransferase activity
GO:0000287	IEA:InterPro	F	magnesium ion binding
GO:0008171	TAS:ProtInc	F	O-methyltransferase activity
GO:0016036	IEA:Ensembl	P	cellular response to phosphate starvation
GO:0042420	IEA:Ensembl	P	dopamine catabolic process
GO:0008210	IEA:Ensembl	P	estrogen metabolic process
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0007612	IEA:Ensembl	P	learning
GO:0032259	TAS:Reactome	P	methylation
GO:0048609	IEA:Ensembl	P	multicellular organismal reproductive process
GO:0045963	IEA:Ensembl	P	negative regulation of dopamine metabolic process
GO:0048662	IEA:Ensembl	P	negative regulation of smooth muscle cell proliferation
GO:0042136	TAS:Reactome	P	neurotransmitter biosynthetic process
GO:0042135	IEA:UniProtKB-KW	P	neurotransmitter catabolic process
GO:0050668	IEA:Ensembl	P	positive regulation of homocysteine metabolic process
GO:0042493	IEA:Ensembl	P	response to drug
GO:0032496	IEA:Ensembl	P	response to lipopolysaccharide
GO:0014070	IEA:Ensembl	P	response to organic cyclic compound
GO:0048265	IEA:Ensembl	P	response to pain
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0007268	TAS:Reactome	P	synaptic transmission
GO:0006805	TAS:Reactome	P	xenobiotic metabolic process

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04728	Dopaminergic synapse
ko04728	Dopaminergic synapse
hsa01100	Metabolic pathways
hsa00140	Steroid hormone biosynthesis
ko00140	Steroid hormone biosynthesis
hsa00350	Tyrosine metabolism
ko00350	Tyrosine metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY6666-2	dopamine degradation
PWY6666-2	dopamine degradation
PWY-6334	L-dopa degradation
PWY-6342	noradrenaline and adrenaline degradation
PWY-6342	noradrenaline and adrenaline degradation

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_13433	Biological oxidations
REACT_15514	Dopamine clearance from the synaptic cleft
REACT_15548	Enzymatic degradation of dopamine by COMT
REACT_15511	Enzymatic degradation of Dopamine by monoamine oxidase
REACT_111217	Metabolism
REACT_6946	Methylation
REACT_13685	Neuronal System
REACT_13583	Neurotransmitter Clearance In The Synaptic Cleft
REACT_6959	Phase II conjugation
REACT_13477	Transmission across Chemical Synapses