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MT000960

Record overview

MITO IDMT000960
Gene ID27113
SpeciesHomo sapiens (Human)
Gene NameBCL2 binding component 3
Gene SymbolBBC3
SynonymsJFY1; PUMA; JFY-1;
Alternate namesbcl-2-binding component 3; p53 up-regulated modulator of apoptosis;
Chromosome19
Map Location19q13.3-q13.4
SummaryThis gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
OrthologsView orthologs and multiple alignments for BBC3

Proteins

bcl-2-binding component 3 isoform 1
Refseq ID:NP_001120712
Protein GI:187829730
UniProt ID:Q96PG8
mRNA ID:NM_001127240
Length:261
RefSeq Status:
MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLPARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPT
RRHRRPGGFPLAWGSPQPAPRPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGGRPQRTVRAAETRGAAAAPPL
TLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDSGGRPLPPPDTLASAGDFLCTM
 
bcl-2-binding component 3 isoform 2
Refseq ID:NP_001120713
Protein GI:187829742
UniProt ID:Q9BXH1
mRNA ID:NM_001127241
Length:131
RefSeq Status:
MKFGMGSAQACPCQVPRAASTTWVPCQICGPQPSLSLAEQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQR
HRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN
 
bcl-2-binding component 3 isoform 3
Refseq ID:NP_001120714
Protein GI:187829745
UniProt ID:Q96PG8
mRNA ID:NM_001127242
Length:101
RefSeq Status:
MKFGMGSAQACPCQVPRAASTTWVPCQICETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDSGGRPLPPPDTLASAGDFLCT
M
 
bcl-2-binding component 3 isoform 4
Refseq ID:NP_055232
Protein GI:15193488
UniProt ID:Q9BXH1
mRNA ID:NM_014417
Length:193
RefSeq Status:
MARARQEGSSPEPVEGLARDGPRPFPLGRLVPSAVSCGLCEPGLAAAPAAPTLLPAAYLCAPTAPPAVTAALGGSRWPGGPRSRPRGPRPDGPQPSLSLA
EQHLESPVPSAPGALAGGPTQAAPGVRGEEEQWAREIGAQLRRMADDLNAQYERRRQEEQQRHRPSPWRVLYNLIMGLLPLPRGHRAPEMEPN