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MT000960

UniProt Annotations

Entry Information

Gene Name	BCL2 binding component 3
Protein Entry	BBC3_HUMAN
UniProt ID	Q9BXH1
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=PUMA alpha; IsoId=Q9BXH1-1; Sequence=Displayed; Name=2; Synonyms=PUMA beta; IsoId=Q9BXH1-2; Sequence=VSP_012238; Name=3; Synonyms=PUMA delta; IsoId=Q96PG8-1; Sequence=External; Name=4; Synonyms=PUMA gamma; IsoId=Q96PG8-2; Sequence=External;
Domain	The BH3 motif is intrinsically disordered. {ECO:0000269\|PubMed:23340338}.
Function	Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis. {ECO:0000269\|PubMed:11463391, ECO:0000269\|PubMed:23340338}.
Induction	By DNA damage, glucocorticoid treatment, growth factor deprivation and p53. By ER stress in a DDIT3/CHOP-dependent manner. {ECO:0000269\|PubMed:11463392, ECO:0000269\|PubMed:11572983, ECO:0000269\|PubMed:22761832}.
Interaction	P10415:BCL2; NbExp=5; IntAct=EBI-519884, EBI-77694; Q07817-1:BCL2L1; NbExp=7; IntAct=EBI-519884, EBI-287195; Q92843:BCL2L2; NbExp=2; IntAct=EBI-519884, EBI-707714; Q07820:MCL1; NbExp=3; IntAct=EBI-519884, EBI-1003422; P97287:Mcl1 (xeno); NbExp=5; IntAct=EBI-519884, EBI-707292;
Similarity	Belongs to the Bcl-2 family. {ECO:0000305}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:11463391, ECO:0000269\|PubMed:11463392, ECO:0000269\|PubMed:11572983}. Note=Localized to the mitochondria in order to induce cytochrome c release.
Subunit	Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL. {ECO:0000250, ECO:0000269\|PubMed:11463391, ECO:0000269\|PubMed:23340338}.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269\|PubMed:11463391}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/BBC3ID759ch19q13.html";