MitoProteome Database

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MT000960

Gene Information

Entrez Gene ID27113
Gene NameBCL2 binding component 3
Gene SymbolBBC3
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 TAS:ReactomeCcytosol
GO:0005741 TAS:ReactomeCmitochondrial outer membrane
GO:0005739 IDA:UniProtKBCmitochondrion
GO:0006919 IDA:UniProtKBPactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006915 TAS:ReactomePapoptotic process
GO:0097190 IDA:UniProtKBPapoptotic signaling pathway
GO:0006974 ISS:BHF-UCLPcellular response to DNA damage stimulus
GO:0071456 IEP:UniProtKBPcellular response to hypoxia
GO:0008340 ISS:BHF-UCLPdetermination of adult lifespan
GO:0097194 IDA:UniProtKBPexecution phase of apoptosis
GO:0097193 TAS:ReactomePintrinsic apoptotic signaling pathway
GO:0070059 ISS:UniProtKBPintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0032471 IDA:UniProtKBPnegative regulation of endoplasmic reticulum calcium ion concentration
GO:0045926 IMP:UniProtKBPnegative regulation of growth
GO:2001056 ISS:UniProtKBPpositive regulation of cysteine-type endopeptidase activity
GO:2001244 IMP:UniProtKBPpositive regulation of intrinsic apoptotic signaling pathway
GO:0043525 ISS:UniProtKBPpositive regulation of neuron apoptotic process
GO:0032464 IDA:UniProtKBPpositive regulation of protein homooligomerization
GO:1900740 IDA:UniProtKBPpositive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0090200 IDA:UniProtKBPpositive regulation of release of cytochrome c from mitochondria
GO:0070245 ISS:BHF-UCLPpositive regulation of thymocyte apoptotic process
GO:0001836 IDA:UniProtKBPrelease of cytochrome c from mitochondria
GO:0051209 IDA:UniProtKBPrelease of sequestered calcium ion into cytosol
GO:0034976 IDA:UniProtKBPresponse to endoplasmic reticulum stress
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04390Hippo signaling pathway
ko04390Hippo signaling pathway
hsa05016Huntington's disease
ko05016Huntington's disease
hsa05162Measles
ko05162Measles
hsa04115p53 signaling pathway
ko04115p53 signaling pathway
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_697Activation of BH3-only proteins
REACT_121Activation of PUMA and translocation to mitochondria
REACT_578Apoptosis
REACT_330BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REACT_964Intrinsic Pathway for Apoptosis