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MitoProteome Human Mitochondrial Protein Database
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Related Proteins
MT001081
UniProt Annotations
Entry Information
Gene Name
cytochrome c, somatic
Protein Entry
CYC_HUMAN
UniProt ID
P99999
Species
Human
Comments
Comment type
Description
Disease
Thrombocytopenia 4 (THC4) [MIM:612004]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. {ECO:0000269|PubMed:18345000}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
Function
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.
Interaction
O14727:APAF1; NbExp=6; IntAct=EBI-446479, EBI-446492; Q07817:BCL2L1; NbExp=2; IntAct=EBI-446479, EBI-78035;
Ptm
Binds 1 heme group per subunit.
Ptm
Phosphorylation at Tyr-49 and Tyr-98 both reduce by half the turnover in the reaction with cytochrome c oxidase, down- regulating mitochondrial respiration. {ECO:0000250}.
Similarity
Belongs to the cytochrome c family. {ECO:0000305}.
Subcellular Location
Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.
Web Resource
Name=Protein Spotlight; Note=An unexpected place - Issue 88 of November 2007; URL="http://web.expasy.org/spotlight/back_issues/088/";
Web Resource
Name=Protein Spotlight; Note=Life shuttle - Issue 76 of November 2006; URL="http://web.expasy.org/spotlight/back_issues/076";
MitoProteome Human Mitochondrial Protein Database
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