MitoProteome Database

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MT001451

Record overview

MITO IDMT001451
Gene ID90427
SpeciesHomo sapiens (Human)
Gene NameBcl2 modifying factor
Gene SymbolBMF
Alternate namesbcl-2-modifying factor;
Chromosome15
Map Location15q14
SummaryThe protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BMF

Proteins

bcl-2-modifying factor isoform bmf-1
Refseq ID:NP_277038
Protein GI:15723378
UniProt ID:Q96LC9
mRNA ID:NM_033503
Length:184
RefSeq Status:
MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNA
GYRLPLPASFPAVLPIGEQPPEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR
 
bcl-2-modifying factor isoform bmf-1
Refseq ID:NP_001003940
Protein GI:51558688
UniProt ID:Q96LC9
mRNA ID:NM_001003940
Length:184
RefSeq Status:
Protein sequence is identical to GI:15723378 (mRNA isoform)
 
bcl-2-modifying factor isoform bmf-2
Refseq ID:NP_001003942
Protein GI:51558701
UniProt ID:Q96LC9
mRNA ID:NM_001003942
Length:163
RefSeq Status:
MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYGNA
GYRLPLPASFPAVLPIGEQPPEGQWQHQAEHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR
 
bcl-2-modifying factor isoform bmf-3
Refseq ID:NP_001003943
Protein GI:51558704
UniProt ID:Q96LC9
mRNA ID:NM_001003943
Length:129
RefSeq Status:
MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSQGVMLPCGVTEEPQRLFYAPA
EPKSCVVADPPLPAQPCFEWRREQERGRP