MitoProteome Database

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MT001451

UniProt Annotations

Entry Information

Gene Name	Bcl2 modifying factor
Protein Entry	BMF_HUMAN
UniProt ID	Q96LC9
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=BMF-I; IsoId=Q96LC9-1; Sequence=Displayed; Name=2; Synonyms=BMF-II; IsoId=Q96LC9-2; Sequence=VSP_012292; Name=3; Synonyms=BMF-III; IsoId=Q96LC9-3; Sequence=VSP_012293, VSP_012294;
Function	May play a role in apoptosis. Isoform 1 seems to be the main initiator.
Sequence Caution	Sequence=AAH60783.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15762.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the Bcl-2 family. {ECO:0000305}.
Subunit	Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. {ECO:0000269\|PubMed:14574334}.